Clinical Trials

According to our plan for dissemination and implementation of results, the objectives and work plan for the UM Cure 2020 project have been designed to generate results and evidence as grounds for improving our knowledge of metastatic UM and lead to an effective treatment of metastatic disease in UM patients. Being put forward as a continuum from basic research through to the preclinical validation of new therapeutic approaches and ultimate initiation of clinical trials, UM Cure 2020 is expected to deliver the following (among others):

1. New therapies validated at the preclinical level, using molecules in development (single or in combination) and the repositioning of already approved molecules (WP2); 
2. A UM-specific chip designed by partner PG (WP4), aiming at helping stratify patients in clinical trials; 
3. Improved detailed knowledge on the pathophysiology of UM, and in particular of the metastatic disease (WP4); 
4. New relevant preclinical models to test therapeutic interventions and to further increase our knowledge of disease mechanisms (WP3).

As the project progresses, these should lead to the initiation of at least one clinical trial dedicated to metastatic UM patients.

UM CURE 2020 Clinical trials will be posted here.

Finding Current Clinical Trials 

ClinicalTrials.gov

 

The most complete and user-friendly website provided by the US NIH also listing many European trials.

The provided tutorial and glossary may be of use to facilitate understanding of the information obtained through the portal.

Talking to your doctor beforehand can be beneficial to obtain some guidance of which trials might be useful to your particular situation.

Trials currently recruiting patients can be found following these steps:

 

1. Typing “uveal melanoma” in the “Condition or disease” box:

2. If desired, a specific country may be selected. For example, to identify clinical trials in Germany:

3. Clicking on “Search” to advance to the complete listing of clinical trials that match the restrictions applied

4. In the Status box selecting “Recruiting” and then “Apply” to list trials currently recruting patients:

 

 

After selecting a clinical trial of your interest , you will find the description of the study, including the protocol, inclusion and exclusion criteria and a list with locations at the bottom of the page.

European based trials are not as detailed, but a reliable email contact can be found for further information.

 

 

EU Clinical Trials Register​

The search engine lists existing clinical trials in Europe, providing extensive technical information in the search page which can sometimes be difficult to read through.   

Nonetheless, details listed by European country and the trial sponsor contact information can be found under Point B.5, after a specific clinical trial is chosen.