Transcriptome Profiling Reveals New Insights into the Immune Microenvironment in Metastatic Uveal Melanoma

Our partners at the University of Liverpool studied which type of immune cells arise in the liver in response to UM metastases as well as which type of molecules UM metastases produce. These findings can be the first step to delevop new treatments against metastatic UM. 

Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma

 

Uveal melanoma (UM) is a rare aggressive eye cancer. Although treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of their cancer in the liver. At present, such advanced disease is not curable. A better understanding of the metastatic UM (mUM) in the liver is essential to improve patient survival.

This study examined both the response of immune cells within the liver to the UM secondaries (metastases), as well as the expression of various proteins by the UM cells. The study demonstrated that although there is a limited immune response to the mUM, a specific type immune cell does appear to be present. These findings can be the first step to delevop new treatments against metastatic UM.

You can read the full paper here.