Researchers at the Laboratory of Preclinical Investigation at the Institut Curie in Paris (France) have been developing animal models of human uveal melanoma and liver metastases as early tools in drug development.
This work, conducted by Dr. Alda Rola from the Liverpool Ocular Oncology Research Group (LOORG) led by Professor Sarah Coupland, aims to find out the effectiveness of the LUMPO3 in predicting how often uveal melanoma patients should have liver scans
Professor Rubens Belfort Neto, MD, PhD, explains how radiation works in the treatment of uveal melanoma.
In the last UM Cure 2020 Patient’s meeting, Dr. Emma Dorris ran a workshop entitled “The Art of writing to be understood”, where early career researchers worked with experienced patients on previously published research summaries.
Having taken place at Liverpool University, in Liverpool, England, from the 29th to the 1st of December, this was a unique gathering that emphasized the importance of consortia as driving forces for the development of new therapies for uveal melanoma.
Professor Rubens Belfort Neto, MD, PhD, explains why brachytherapy is used in the treatment of uveal melanoma.
In this video, Tamara Rimmer, uveal melanoma patient and Ocumel UK Patient Advocate, explains how a patient becomes a patient advocate.
In this video, Tamara Rimmer, uveal melanoma patient and Ocumel UK Patient Advocate, talks about the role of Patients' Groups.
In this video Dr. Jesse Berry explains how and why to perform a biopsy in a patient with uveal melanoma.
Professor Rubens Belfort Neto, MD, PhD, discusses the differences between radiation and enucleation for the treatment of uveal melanoma.
In this video Dr. Jesse Berry talks about the importance of referral centres in the treatment of uveal melanoma and the crucial role of patient organizations.
In this video, Tamara Rimmer, uveal melanoma patient and Ocumel UK Patient Advocate, talks about why it is advantageous, for both patients and physicians, to have better informed patients regarding their disease.
In this video Dr. Jesse Berry explains the concept of liquid biopsies.
In this video Dr. Jesse Berry explains the differences between uveal melanoma and retinoblastoma.
The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation."
Professor Ruben Belfort Neto, MD, PhD, talks about how the treatment of the primary tumour (in the eye) affects the development of metastatic disease (most often in the liver).
Professor Ruben Belfort Neto, MD, PhD, talks about the importance of patient groups' when dealing with uveal melanoma.
Sarah Coupland (MD, PhD) and Hans Grossniklaus (MD, PhD) discuss the importance of pathology and why it should not become a dying art.
A Symposium to commemorate this occasion took place in Collegium Maius of Jagiellonian University in Krakow on Sept 7th, 2018.
Professor Ruben Belfort Neto, MD, PhD, talks about the concept of risk factors in uveal melanoma
Dealing with cancer has not only a physical but may also have a mental impact in the patients and in those that support them.
The National Cancer Institute created an important segment on suggestions on how to deal with feelings that may arise during the process.
Interview with Jacqueline Franken from the Stichting Melanoom organization at the MPNE Rare 2017 conference
Recently published on Ophthalmology, a paper from one of our partners explains to the Ophthalmology community the breakthroughs that were achieved with the TCGA project.
In this study, the authors used UM PDXs to evaluate the efficacy of the selumetinib, a targeted therapy medication aimed at blocking a specific part of one of the pathways responsible for the appearance of UM cancer cells, alone or in combination with other therapies.
Interview with Andrew Evans at the Melanoma Patient Network Europe Rare 2017 conference.
As the ARVO Ocular Oncogenesis and Oncology Conference comes to an end we cannot help but smile when looking back and see all that was achieved during these past days.
Dr. Sergio Roman-Roman talked about recent findings regarding uveal melanoma at the 25th Biennial Congress of the European Association for Cancer Research.
The World Ophthalmology Congress, organized by the International Council of Ophthalmology, was an outstanding meeting! It was really motivating to see how multiple groups across the world are fighting uveal melanoma, both in the clinic and research settings.
In this paper, the authors discuss the various treatments evaluated in the setting of metastatic uveal melanoma, including systemic chemotherapy, immunotherapy, targeted agents against the MAPK pathway, and liver-directed therapies.
For the past four years Dr. Mehmet Doğrusöz from the Leiden University performed research under the supervision of Prof. Martine J. Jager and studied genetic prognostic parameters in uveal melanoma.
“Together with a better understanding of the biology of the disease and the recent delivery of relatively large studies, this holds hope that new and more effective treatment options will become available for UM patients with metastatic disease in the near future.”
The PhD Thesis defense took place at Institut Curie the 29th of May, 2018
Congratulations to Institut Curie for the great work.
Congratulations to Professor Richard Marais, UMCURE2020 consortium member, for being elected as Fellow of the Royal Society.
The Association for Research in Vision and Ophthalmology (ARVO) has presented Professor Sarah Coupland with a ‘Distinguished Service Award’ at the 2018 Association’s annual meeting.
The UMCure 2020 consortium has been profiled by Science Impact, a series of high-quality science reports designed to enable the dissemination of research impact to all.
In patients with metastatic uveal melanoma, the combination of selumetinib plus dacarbazine had a tolerable safety profile but did not significantly improve PFS compared with placebo plus dacarbazine. Despite the results of this study, additional assessment of MEK inhibitors in uveal melanoma is warranted.
The 2017 American Society of Clinical Oncology (ASCO) Annual Meeting was held in Chicago, Illinois, 2nd-6th June 2017.
Having taken place on 18th January at the Institut Curie in Paris, France, the second meeting of the UM Cure 2020 Scientific Advisory Board (SAB) gave UMCure 2020 SAB members and partners the chance to consider the consortium's successes obtained during its first two years, as well as look forward to the work ahead.
José Baselga received the ESMO Lifetime Achievement Award, celebrating a four-decade career of outstanding relevance in clinical oncology, at the ESMO 2017 conference in Madrid, in his native Spain.
Their Royal Highnesses Queen Maxima and King Willem-Alexander of the Netherlands visited the Champalimaud Centre for the Unknown on 11th October 2017, where they were presented to the UMCure 2020 project.
MPNE Rare 2017 was held this past weekend in Leiden University Medical Center, Netherlands.
An international team, which includes several UMCure 2020 participants, has just identified four distinct UM subtypes with clinical relevance.
Having taken place at Jagiellonian University, in Krakow, Poland, June 15-17 2017, this was a unique gathering that emphasized the importance of consortia as driving forces for the development of new therapies for rare diseases.
"Enthusiasm gets things done."
Our congratulations to Professor Coupland!
24 - 27th March 2017 at Institut Curie, Paris
A three-year postdoctoral position funded by the EU Horizon 2020 Programme is available in the laboratory of Prof. Richard Marais to identify and validate novel therapeutic approaches for the treatment of metastatic uveal melanoma (UM).
UM Cure 2020 joins in the celebration.
Professor Sarah Coupland, head of the Liverpool Ocular Oncology Group, was elected Vice-president of the Association for Research in Vision and Ophthalmogy, one the foremost scientific organizations in opthalmology worldwide.