In this paper, the authors discuss the various treatments evaluated in the setting of metastatic uveal melanoma, including systemic chemotherapy, immunotherapy, targeted agents against the MAPK pathway, and liver-directed therapies.
For the past four years Dr. Mehmet Doğrusöz from the Leiden University performed research under the supervision of Prof. Martine J. Jager and studied genetic prognostic parameters in uveal melanoma.
“Together with a better understanding of the biology of the disease and the recent delivery of relatively large studies, this holds hope that new and more effective treatment options will become available for UM patients with metastatic disease in the near future.”
The PhD Thesis defense took place at Institut Curie the 29th of May, 2018
Congratulations to Institut Curie for the great work.
Congratulations to Professor Richard Marais, UMCURE2020 consortium member, for being elected as Fellow of the Royal Society.
The Association for Research in Vision and Ophthalmology (ARVO) has presented Professor Sarah Coupland with a ‘Distinguished Service Award’ at the 2018 Association’s annual meeting.
The UMCure 2020 consortium has been profiled by Science Impact, a series of high-quality science reports designed to enable the dissemination of research impact to all.
In patients with metastatic uveal melanoma, the combination of selumetinib plus dacarbazine had a tolerable safety profile but did not significantly improve PFS compared with placebo plus dacarbazine. Despite the results of this study, additional assessment of MEK inhibitors in uveal melanoma is warranted.
The 2017 American Society of Clinical Oncology (ASCO) Annual Meeting was held in Chicago, Illinois, 2nd-6th June 2017.
Having taken place on 18th January at the Institut Curie in Paris, France, the second meeting of the UM Cure 2020 Scientific Advisory Board (SAB) gave UMCure 2020 SAB members and partners the chance to consider the consortium's successes obtained during its first two years, as well as look forward to the work ahead.
José Baselga received the ESMO Lifetime Achievement Award, celebrating a four-decade career of outstanding relevance in clinical oncology, at the ESMO 2017 conference in Madrid, in his native Spain.
Their Royal Highnesses Queen Maxima and King Willem-Alexander of the Netherlands visited the Champalimaud Centre for the Unknown on 11th October 2017, where they were presented to the UMCure 2020 project.
MPNE Rare 2017 was held this past weekend in Leiden University Medical Center, Netherlands.
An international team, which includes several UMCure 2020 participants, has just identified four distinct UM subtypes with clinical relevance.
Having taken place at Jagiellonian University, in Krakow, Poland, June 15-17 2017, this was a unique gathering that emphasized the importance of consortia as driving forces for the development of new therapies for rare diseases.
"Enthusiasm gets things done."
Our congratulations to Professor Coupland!
24 - 27th March 2017 at Institut Curie, Paris
A three-year postdoctoral position funded by the EU Horizon 2020 Programme is available in the laboratory of Prof. Richard Marais to identify and validate novel therapeutic approaches for the treatment of metastatic uveal melanoma (UM).
UM Cure 2020 joins in the celebration.
Professor Sarah Coupland, head of the Liverpool Ocular Oncology Group, was elected Vice-president of the Association for Research in Vision and Ophthalmogy, one the foremost scientific organizations in opthalmology worldwide.